Review”The book covers a wide range of topics and, as such, it will serve as a valuable reference for pharmaceutical scientists, toxicologists, academicians, and the graduate students.” (Doody’s, May 2009)
Review”This is an splendid book, which is very well suitable for both teachers and newcomers to the field, who may use it as a starting point for further in-depth studies of the applicable literature. Experienced researchers from dissimilar disciplines will get the rapid introduction they desire and learn when it comes to the respective distinct elements connected to drug bioavailability.”
—Sven Grüneberg, Stefan Güssregen, Chemistry, Computational Chemistry, Aventis Pharma Deutschland GmbH, Frankfurt a.M., Angewandte Chemie and Angewandte Chemie International Edition, 2/04
From the Back CoverIn order to reach it is intended internet site of action, the drug corpuscles in each pill that we swallow must initial be absorbed, transported by way of the bloodstream and evade respective mechanisms that eliminate drugs from the body. Those drug properties that determine, for example, it is stability in the gut or it is ease of uptake into the bloodstream, are consequently of central importance in drug development. In fact, numerous potentially utile drugs fail because of insufficient availability at the biological target site.
This second edition of the gold usual for industrial exploration is exhaustively revised in line with current trends in the field, with all contributions spacious altered or rewritten. No other publication offers the same level of treatment on this necessary topic.
In 22 chapters readers may gain from the key working cognition of today’s leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the components governing drug bioavailability, finish with practical examples and real-life data.
Part I focuses on solubility and gastrointestinal absorption, while the second discusses in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and solubility. Part III is committed to metamorphosis and excretory mechanisms. The much revised and expanded Part IV surveys current in silico approaches to predict drug properties necessitated to estimate the bioavailability of any new drug candidate. The final share shows new drug development approaches as well as deliverance strategies.
Indispensable for all those working in the pharmaceutical industry, pharmaceutical and medicinal chemists, and toxicologists.
